Doug Schirch

Leadership of Study Abroad Units

• Co-leader of Study and Sports in the Dominican Republic, May 2019.
• Co-leader of Study-Service Term in Peru for three semesters in 2016-2017.
• Co-leader of Study and Sports in Nicaragua, May 2016.
• Co-leader of Study-Service Term in Nicaragua during the summers of 2008 and 2013.

Employment History

• July 2010-present

  Professor of Chemistry, Goshen College, Goshen, IN.

   

• 2004-2010

  Associate Professor of Chemistry, Goshen College, Goshen, IN.

   

• 2002-2004

  Academic Dean, Ave Maria College of the Americas, Nicaragua.

   

• 2000-2004

  Associate Professor of Chemistry, Ave Maria College of the Americas, Nicaragua.

   

• 1997-2000

  Academic Dean, University of Mobile Latin American Campus, Nicaragua.

   

• 1994-2000

  Assistant Professor of Chemistry, University of Mobile Latin American Campus, Nicaragua.

   

• 1992-94

  Postdoctoral research, Medical College of Virginia.

   

• 1987-91

  Team member and Coordinator of Media/Documentation Office, Witness for Peace, Nicaragua.

Participation in distributed drug discovery research.

• Fuller A., Dounay A., Schirch D., Rivera D., Hansford K., Elliott A., Zuegg J, Cooper M., Blaskovich M., Hitchens J., Burris-Hiday S., Tenorio K., Mendez Y., Samaritoni J., O’Donnell M., Scott W.  Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds. ACS Chem Biol. (2020 Dec 18) 15 (12), 3187-3196.
• Dounay, A. B., O’Donnell, M. J., Samaritoni, J. G., Popiolek, L., Schirch, D., Biernasiuk, A., Malm, A., Lamb, I. W., Mudrack, K., Rivera, D. G., Ojeda, J.M., Scott, W.L.  Globally Distributed Drug Discovery of New Antibiotics: Design and Combinatorial Synthesis of Amino Acid Derivatives in the Organic Chemistry Laboratory, J. Chem. Educ. (2019 June 19) 96 (8), 1731-1737.

Chemistry Education.

• Schirch, Douglas.   Flipping an Allied Health Survey Course of Organic and Biological Chemistry, in Active Learning in Organic Chemistry: Implementation and Analysis; ACS Symposium Series; American Chemical Society, (2019) Vol. 1336, pp 149-166.

The novel anti-tumor agent 3-bromopyruvate.

• The antitumor agent 3-bromopyruvate has a short half-life at physiological conditions.  Biochem Biophys Res Commun. (2014 Sep 12) 452(1):170-3.
• Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.  Biochim Biophys Acta. (2016 Aug 13) 1864(11):1506-1517.

Selected Publications

• Fuller A., Dounay A., Schirch D., Rivera D., Hansford K., Elliott A., Zuegg J, Cooper M., Blaskovich M., Hitchens J., Burris-Hiday S., Tenorio K., Mendez Y., Samaritoni J., O’Donnell M., Scott W. Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds. ACS Chem Biol. (2020 Dec 18) 15 (12), 3187-3196.
• Dounay, A. B., O’Donnell, M. J., Samaritoni, J. G., Popiolek, L., Schirch, D., Biernasiuk, A., Malm, A., Lamb, I. W., Mudrack, K., Rivera, D. G., Ojeda, J.M., Scott, W.L. Globally Distributed Drug Discovery of New Antibiotics: Design and Combinatorial Synthesis of Amino Acid Derivatives in the Organic Chemistry Laboratory, J. Chem. Educ. (2019 June 19) 96 (8), 1731-1737.
• Schirch, Douglas. Flipping an Allied Health Survey Course of Organic and Biological Chemistry, in Active Learning in Organic Chemistry: Implementation and Analysis; ACS Symposium Series; American Chemical Society, (2019) Vol. 1336, pp 149-166.
• Alessandro Paiardini, Angela Tramonti, Doug Schirch, Giulia Guiducci, Martino Luigi di Salvo, Alessio Fiascarelli, Alessandra Giorgi, Bruno Maras, Francesca Cutruzzolà, Roberto Contestabile, Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming. Biochim Biophys Acta. (2016 Aug 13); 1864(11):1506-1517.
• Matthew Glick, Perry Biddle, Josh Jantzi, Samantha Weaver, Doug Schirch. The antitumor agent 3-bromopyruvate has a short half-life at physiological conditions, (2014) Biochem. Biophys. Res. Commun. 452 (1), 170-3.
• AudioSlides presentation of The antitumor agent 3-bromopyruvate has a short half-life at physiological conditions.
• Kim, D.W., Huang, T., Schirch, D., and Schirch, V. The Properties of Tetrahydropteroylpentaglutamate Bound to 10-Formyltetrahydrofolate Dehydrogenase, (1996). Biochem . 35 (49), 15772-15783.
• Cai, K., Schirch, D., and Schirch, V. The Affinity of Pyridoxal 5′-Phosphate for Folding Intermediates of Escherichia coli Serine Hydroxymethyltransferase, (1995) J. Biol. Chem. 270 (33), 19294-19299.
• Schirch, D.M., Villar, E., Maras, B., Barra, D., and Schirch, V. Domain Structure and Function of 10-Formyltetrahydrofolate Dehydrogenase, (1994) J. Biol. Chem., 269 (40), 24728-24735.
• Schirch, D.M., delle Frate, S., Iurescia, S., Angelaccio, S., Contestabile, R., Bossa, F., and Schirch, V. Serine Hydroxymethyltransferase: Role of the Active Site Lysine in the Mechanism of the Enzyme, (1993) Adv. Exp. Med. Biol. 338, 715-718.
• Schirch, D.M., Contestabile, R., delle Frate, S., Iurescia, S., Angelaccio, S., Bossa, F., and Schirch, V. Function of the Active Site Lysine in Serine Hydroxymethyltransferase, (1993) J. Biol. Chem., 268 (31), 23132-23138.
• Schirch, D.M. Location and Structure of the Hexose Binding Site of Rat Brain Hexokinase, (1986) Ph.D. Dissertation Thesis, Michigan State University.
• Schirch, D.M. and Wilson, J.E. Rat Brain Hexokinase: Amino Acid Sequence at the Substrate Hexose Binding Site is Homologous to that of Yeast Hexokinase, (1987) Arch. Biochem. Biophys., 257, 1-12.
• Schirch, D.M. and Wilson, J.E. Rat Brain Hexokinase: Location of the Substrate Hexose Binding Site in a Structural Domain at the C-Terminus of the Enzyme, (1987) Arch. Biochem. Biophys., 254, 385-396.
• Schirch V., Schirch, D., Martini, F., and Bossa, F. Serine Hydroxymethyltransferase: Effect of Proteases on the Activity and Structure of the Cytosolic Enzyme, (1986) Eur . J. Biochem., 161, 45-49.

Recent Presentations

• AAC&U Conference on “Transforming STEM Education,” Nov. 2023, Arlington, VA:
• Incorporation of metacognition and mindfulness instruction into majors and non-majors chemistry courses.  [PPTX]
• American Chemical Society National Meeting, Aug. 2022, Chicago, IL:
• Evaluations of weekly short metacognitive interventions in first- and second-year chemistry courses
• American Chemical Society National Meeting, April 2019, Orlando, FL:
• Flipping and restructuring an OB course: Improved student performances and positive longitudinal student survey responses
• 25th Biennial Conference on Chemical Education, 2018, Notre Dame University, South Bend, Indiana:
• A spiral organic chemistry sequence, 12 years after implementation [PPTX] [PDF]
• Student perspectives on a flipped OB course at course completion and 2-3 years later  [PPTX] [PDF]
• 24th Biennial Conference on Chemical Education, 2016, University of Northern Colorado, Greeley, CO:
• Successful conversion of confirmation labs to a simulated research project in a GOB course.  [PPT]  [PDF]